Duke Clinical Research Institute

Durham, North Carolina 72205

4 studies enrolling now · 53 studies all time

What they study most

ASCVD, Acute Myeloid Leukemia, Acute Pain, Arterial Thromboembolic Events, Atrial Fibrillation, Auto-inflammatory Disease, Bacterial Infections, COVID-19, Chronic Hepatitis C Infection, Chronic Lung Disease, Coronary Artery Bypass Graft Surgery, Covid19

Studies at this site

• A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN) — Recruiting now
• A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM). — Recruiting now
• Clinical Study To Further Evaluate The Efficacy Of Dabrafenib Plus Trametinib In Patients With Rare BRAF V600E Mutation-Positive Unresectable or Metastatic Solid Tumors — Recruiting now
• COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children — Recruiting now
• ACHIEVE Pilot Statins for Vascular Protection — Completed
• Phase 2 Study of Rapcabtagene Autoleucel in Myositis — Running, not enrolling
• A Study to Evaluate the Efficacy and Safety of Birtamimab in Mayo Stage IV Patients With AL Amyloidosis — Stopped early
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin) — Completed
• ACTIV-6: COVID-19 Study of Repurposed Medications — Completed
• Study of Access Site for Enhancing PCI in STEMI for Seniors (SAFE STEMI for Seniors) — Stopped early
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm F (Montelukast) — Completed
• Survey Based Discrete Choice Experiment Study in Prostate Cancer (DECIDER) Study — Completed
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100) — Completed
• Remote Monitoring of the Diabetic Foot to Prevent Re-Ulceration — Stopped early
• Evaluating Comparative Effectiveness of Empagliflozin in Type 2 Diabetes Population With and Without Chronic Kidney Disease — Completed
• Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML) — Completed
• Individual Patient Exposure and Response in Pediatric Lupus — Completed
• Study of ISB 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma — Completed
• A Study to Assess the Safety of BMS-984923 Compared to Placebo, in People With Parkinson's — Status unconfirmed
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm D (Ivermectin 600) — Completed
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm B (Fluvoxamine) — Completed
• Healthcare Worker Exposure Response and Outcomes (HERO) Registry Study, COVID-19 — Completed
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm C (Fluticasone) — Completed
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm A (Ivermectin 400) — Completed
• Efficacy and Safety Study of Pegylated Interferon Lambda-1a With Ribavirin and Daclatasvir, to Treat naïve Subjects With Chronic HCV Genotypes 1, 2, 3, and 4 Who Are Co-infected With HIV — Stopped early
• Bempegaldesleukin and Pembrolizumab With or Without Chemotherapy in Locally Advanced or Metastatic Solid Tumors — Stopped early
• Multi-Drug Resistant Organism Network — Completed
• MW151-101: First-in-human Study of MW151 — Completed
• Addition of ISIS 14803 to Therapy With Peginterferon and Ribavirin for Chronic Hepatitis C (HCV) Patients Not Responding Adequately to the Two Drugs — Completed
• Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli (EXPECT-1) — Completed
• Study to Collect Information About Invasive Disease Caused by Extraintestinal Pathogenic Escherichia Coli-2 (EXPECT-2) — Completed
• Infancy to Toddlerhood: Early Nutrition & Tolerance (INTENT) — Status unconfirmed
• Randomized, Double-Blind, Placebo-Controlled, Safety and Tolerability Study of ITI-214 in Patients With Heart Failure — Completed
• Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients — Withdrawn before enrolling
• Examining New Diagnostic Tests for Acute Kidney Injury After Heart Surgery — Completed
• Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC) — Completed
• Safety and Efficacy Study to Compare Continuous Infusion of Interferon With Standard of Care for Chronic Hepatitis C — Completed
• Patient-centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research — Completed
• Long-Term Follow-Up Safety Monitoring of Patients Dosed in the First-in-Man Phase I/II Study of TT-034. — Stopped early
• A Study of Safety, Tolerability & Efficacy of Certican in de Novo Heart Transplant (Tx) Patients — Completed
• Safety and Efficacy Study of Single Doses of TT-034 in Patients With Chronic Hepatitis C — Completed
• Integrated Population Program for Diabetic Kidney Disease — Completed
• Safety Study of CN-105 Neuroprotective Peptide for Intracerebral Hemorrhage — Completed
• Effectiveness of Bridging Anticoagulation for Surgery (The BRIDGE Study) — Completed
• The CARRA Registry — Completed
• Community and Clinician Partnership for Prevention — Completed
• Impact of Maternal-infant Therapeutics on Safety, Mortality, and Disability — Withdrawn before enrolling
• Centers for Education on Research and Therapeutics - Heart Failure: Targeted Intervention Study — Completed
• Safety of KAI-9803 for Injection With Angioplasty Following Heart Attack — Completed
• Adaptive Phase I HCV Study With Nucleoside Analogue, in Combination With Interferon and Ribavirin — Completed