A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)
Recruiting now · Phase 2
Conditions studied: Lupus Erythematosus, Systemic, Lupus Nephritis
In brief
The purpose of this study is to evaluate the efficacy and safety of rapcabtagene autoleucel (administered once following lymphodepletion) in patients with active, refractory systemic lupus erythematosus (SLE) or active, refractory lupus nephritis (LN).
Key facts
- Study ID
- NCT06581198
- Run by
- Novartis Pharmaceuticals
- People needed
- 179
- Starts
- 2024-09-04
- Expected to finish
- 2032-02-06
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Loma Linda University — San Bernardino, California, United States (enrolling)
- UCSF — San Francisco, California, United States (enrolling)
- UCSF — San Francisco, California, United States (enrolling)
- Sutter Health Network — San Pablo, California, United States (enrolling)
- Ann and Robert H Lurie Childs Hosp — Chicago, Illinois, United States (enrolling)
- Northwestern University — Chicago, Illinois, United States (enrolling)
- University Of Iowa — Iowa City, Iowa, United States (enrolling)
- University of Kentucky — Lexington, Kentucky, United States (enrolling)
- Tufts Medical Center — Boston, Massachusetts, United States (enrolling)
- Boston Medical Center — Boston, Massachusetts, United States (enrolling)
- WA Uni School Of Med — St Louis, Missouri, United States (enrolling)
- Duke Clinical Research Institute — Durham, North Carolina, United States (enrolling)
- Oregon Health Sciences University — Portland, Oregon, United States (enrolling)
- Houston Methodist Hospital — Houston, Texas, United States (enrolling)
- Univ Of TX MD Anderson CC — Houston, Texas, United States (enrolling)
- University of Texas MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- LDS Hospital — Salt Lake City, Utah, United States (enrolling)
- LDS Hospital — Salt Lake City, Utah, United States (enrolling)
- Novartis Investigative Site — Clayton, Victoria, Australia (enrolling)
- Novartis Investigative Site — Graz, Austria (enrolling)
- Novartis Investigative Site — Vienna, Austria (enrolling)
- Novartis Investigative Site — Salvador, Estado de Bahia, Brazil (enrolling)
- Novartis Investigative Site — Barretos, São Paulo, Brazil (enrolling)
- Novartis Investigative Site — São Paulo, São Paulo, Brazil (enrolling)
- University Of Alabama — Birmingham, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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