Multi-Drug Resistant Organism Network
Completed
Conditions studied: Infections Resistant to Multiple Drugs, Bacterial Infections
In brief
This study is specifically designed to provide observational data which can be used to help in the design of future randomized clinical trials on both therapeutics and diagnostics for MDRO infections. To this end, clinical and epidemiological data will be collected on patients who have MDRO isolated from clinical cultures during hospitalization, as well as descriptions of the outcomes of patients treated with various antimicrobial regimens. Molecular and microbiological characterization will also be performed on MDRO isolates. These data will include a detailed clinical and epidemiological description of patients including identifying potential barriers to enrollment in future trials. In addition, data will be collected on species, strain type, and mechanism of drug resistance of the causative organism. Knowing the molecular characteristics will further inform future trial design as not all diagnostics detect and not all therapeutics are active against the same mechanisms of resistance.
Key facts
- Study ID
- NCT03646227
- Run by
- Duke University
- People needed
- 6496
- Starts
- 2016-06-16
- Expected to finish
- 2020-05-30
- Last updated by the study team
- 2023-03-06
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Hospitalized patients.
- Must have at least one multi-drug resistant organism isolated from a clinical culture while hospitalized.
You may not qualify if…
- Patients who do not have a positive culture during hospitalization.
- Patients who's only positive culture was obtained outside of hospital admission.
- Patients who have cystic fibrosis and a CRPa infection.
Where it is running
- Duke Clinical Research Institute — Durham, North Carolina, United States
- The University of Queensland Centre for Clinical Research — Herston, Queensland, Australia
- Huashan Hospital — Shanghai, Shanghai Municipality, China
- Universidad El Bosque — Bogotá, Colombia
Full record on ClinicalTrials.gov
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