Massachusetts General Hospital ACTG CRS

Boston, Massachusetts 02114

0 studies enrolling now · 45 studies all time

What they study most

AIDS Dementia Complex, Candidiasis, Oral, Cognition Disorders, Cytomegalovirus Infections, Cytomegalovirus Retinitis, HIV Infections, Hepatitis C, Herpes Zoster, Leukoencephalopathy, Progressive Multifocal, Meningitis, Cryptococcal, Mycobacterium Avium-intracellulare Infection, Peripheral Nervous System Disease

Studies at this site

• Effectiveness of and Immune Response to HIV Vaccination Followed by Treatment Interruption in HIV Infected Patients — Completed
• A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past — Completed
• The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More Than 12 Weeks — Completed
• A Study of Disease Progression and Anti-HIV Treatments — Completed
• A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected Patients — Completed
• Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1 — Completed
• A Phase I/II Trial of Vaccine Therapy of HIV-1 Infected Individuals With 50-500 CD4 Cells/mm3 — Completed
• Combination Pain Therapy in HIV Neuropathy — Stopped early
• A Phase I Comparative Blinded Trial of Several HIV-1 Derived Immunogens in Infected Individuals With >= 500 CD4 Cells/mm3 — Completed
• Live Zoster Vaccine in HIV-Infected Adults on Antiretroviral Therapy — Completed
• A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides — Completed
• A Phase II Double-Blind Study of Delavirdine Mesylate ( U-90152 ) in Combination With Zidovudine ( AZT ) and/or Didanosine ( ddI ) Versus AZT and ddI Combination Therapy — Completed
• Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis — Completed
• Virologic Responses To New Nucleoside Regimens After Prolonged ZDV or ddI Monotherapy — Completed
• Effect of Addition of Raltegravir (MK-0518) to PI- or NNRTI-Based ART Regimens in HIV Infected Subjects With Undetectable Viral Load — Completed
• The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used Saquinavir Hard Gelatin Capsules for One Year — Completed
• A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS — Completed
• A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure — Completed
• A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3 — Completed
• A Phase I/II Open Label Study To Evaluate the Antiviral Potential of Combination Low-Dose Therapy With Zidovudine and Interferon-Alpha 2A in Patients With Symptomatic HIV Disease — Completed
• A Randomized, Double Blind, Comparative Study of Dideoxycytidine (ddC) Alone or ddC/AZT Combination Versus Zidovudine (ZDV) Alone in Patients With HIV Infection Who Have Received Prior ZDV Therapy — Completed
• A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis — Completed
• Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV Patients — Completed
• The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected Patients — Completed
• Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients — Completed
• Comparison of Two Methods in the Treatment of Cytomegalovirus of the Eyes in Patients With AIDS — Completed
• A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients Who Have Not Had Success With Fluconazole — Completed
• Preventing Cytomegalovirus (CMV) Organ Damage With Valganciclovir in People With HIV — Completed
• Immune Responses in HIV-Positive Patients Receiving an Anti-HIV Drug Combination When Given the HIV Vaccines Remune and vCP1452 — Completed
• A Comparison of the Effectiveness, Safety, and Tolerability of Two Different Hepatitis C Treatments in Patients Infected With Both HIV and Hepatitis C Virus (HCV) — Completed
• Safety/Immunogenicity of Immunizations of ALVAC-DC-SC vs ALVAC-SC — Completed
• Effects of Therapeutic HIV Vaccination on Control of HIV After Discontinuation of Anti-HIV Drugs — Completed
• Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients — Completed
• Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults — Completed
• Safety of and Immune Response to a DNA HIV Vaccine (VRC-HIVDNA009-00-VP) in HIV Infected Individuals With Acute HIV Infection — Completed
• Effectiveness of Giving an HIV Vaccine (Remune) to HIV-Positive Patients Receiving an Anti-HIV Drug Combination — Completed
• A Study of HIV-Disease Development in Aging — Completed
• A Study of the Safety and Effectiveness of Hydroxyurea in Patients on Potent Antiretroviral Therapy and Who Have Less Than 200 Copies/ml of HIV RNA in Their Blood — Completed
• Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected With HIV — Completed
• A Study to Evaluate the Effects of Interleukin-12 (rhIL-12) in HIV-Positive Patients With CD4 Cell Counts Less Than 50 Cells/mm3 or 300-500 Cells/mm3 — Completed
• A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection — Completed
• A Phase I/II Study of Recombinant Interleukin-4 in AIDS and Kaposi's Sarcoma — Completed
• Telephone Support to Improve Adherence to Anti-HIV Medications — Stopped early
• Comparison of Three Different Initial Treatments Without Protease Inhibitors for HIV Infection — Completed
• Comparison of Liposomal Doxorubicin Used Alone or in Combination With Bleomycin Plus Vincristine in the Treatment of Kaposi's Sarcoma in Patients With AIDS — Completed