Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina 27599-7305

13 studies enrolling now · 54 studies all time

What they study most

Acute Myeloid Leukemia, Adolescent and Young Adult With Brain Cancer, Advanced Cancer, Advanced Solid Tumors, Aging, Bladder Cancer, Breast Cancer, Cancer, Carcinosarcoma, Central Nervous System Lymphoma, Clear Cell Endometrial Carcinoma, Co-morbidity

Studies at this site

• ATLCAR.CD30.CCR4 for CD30+ HL ATLCAR.CD30.CCR4 Cells — Recruiting now
• Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63) — Recruiting now
• TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer — Recruiting now
• Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells — Recruiting now
• Tirzepatide in Obesity-Driven Endometrial Cancer — Recruiting now
• Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc — Recruiting now
• Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer — Recruiting now
• ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer — Recruiting now
• Digital Art Therapy for Young Cancer Survivors — Recruiting now
• Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors — Recruiting now
• NeoAdjuvant, Spare-Adjuvant (NASA) in Stage IIIB-IV (M1a) Melanoma — Starting soon
• A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery — Running, not enrolling
• Pertuzumab and Trastuzumab as Neoadjuvant Treatment in Patients With HER2-Positive Breast Cancer — Running, not enrolling
• Evaluation of Impact of AI Assistance on Workload Associated w Preparation of Rare Tumor Case Repts — Starting soon
• A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas — Running, not enrolling
• Isa-Pom-Dex in Elderly/Frail Subjects With RRMM — Running, not enrolling
• Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer — Starting soon
• PRO-VISION: Patient Reported Outcomes-Based Monitoring of VEGF-Inhibitor Side Effects in ONcology — Running, not enrolling
• Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma — Stopped early
• Pharmacokinetic and Safety Study of MRX-2843 in Adults With Relapsed/Refractory Advanced and/or Metastatic Solid Tumors — Completed
• Immune Reconstitution Monitoring and Pneumococcal Vaccination in Patients Treated With CAR-T Cells — Withdrawn before enrolling
• Physical Activity and Healthy Eating Among Young Adult Cancer Survivors — Completed
• Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian — Running, not enrolling
• Ropidoxuridine as a Radiosensitizer in Newly Diagnosed IDH-Wildtype Glioblastoma With Unmethylated MGMT Promoter — Stopped early
• Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer — Running, not enrolling
• Understanding What Matters Most to Patients: Establishing the Validity of a Best-Worst Scaling Survey — Completed
• Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients — Completed
• Patient and Care Partner Experiences Living With Multiple Myeloma (PaCE-MM) — Stopped early
• 18-FLT PET/MR Imaging to Predict Graft Failure and GVHD in Bone Marrow Transplant Patients — Stopped early
• A Study of ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML) — Stopped early
• A Comparator Study of a Tasso Device Blood Sample to Traditional Venous Blood Sample for CBC — Status unconfirmed
• Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast Cancer — Completed
• Window of Opportunity Pilot Study of Pembrolizumab in Obesity-driven Endometrial Cancer — Stopped early
• Pembrolizumab TX-naive Distant Mets Melanoma and Use of (C11-AMT) PET at Baseline as Imaging Biomarker — Completed
• Study Of Single-dose Cyclophosphamide +Pembrolizumab In Patients With Metastatic Triple Negative Breast Cancer — Completed
• A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion — Stopped early
• Stereotactic Radiosurgery or Other Local Ablation Then Erlotinib in Epidermal Growth Factor Receptor (EGFR) — Completed
• Imaging Correlates of Renal Cell Carcinoma Biological Features — Completed
• Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212 — Completed
• Phase 2 Trial of Seribantumab Plus Fulvestrant in Postmenopausal Women With Metastatic Breast Cancer — Stopped early
• Observational Longitudinal Study of Pain in Men With Metastatic Castrate-Resistant Prostate Cancer — Completed
• AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy — Completed
• Positron Emission Tomography (PET) Study for Staging of Muscle Invasive Bladder Cancer — Completed
• Cancer Patients' Performance Status Assessed Using Cardiopulmonary Exercise Testing and Wearable Data Generation — Completed
• Fitness in Allogeneic Stem Cell Transplantation — Completed
• The Ability of Electronic Patient Symptom Reporting to Reduce Symptom Burden During Hospitalization for Chemotherapy — Completed
• Assessing Physical Fitness in Cancer Patients With Cardiopulmonary Exercise Testing and Wearable Data Generation — Completed
• FOLFIRINOX for Unresectable Locally Advanced and Borderline Resectable Pancreatic Cancer — Stopped early
• Open-label Pilot Evaluating Renal Lesions w/ Contrast-enhaced US in Patients w/ Renal Cancer — Completed
• Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer — Completed