Stroke Volume-based Fluid Resuscitation in AP

Recruiting now · Not applicable

Conditions studied: Acute Pancreatitis (AP)

In brief

The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.

Key facts

Study ID

NCT07756476

Run by

University of Southern California

People needed

80

Starts

2026-03-19

Expected to finish

2028-09-19

Last updated by the study team

2026-08-10

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients between the age of 18-75
• Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment

You may not qualify if…

• Patients with the inability to preform a straight leg raise (i.e amputation)
• Patients with high risk of adverse event related to fluid resuscitation
• NYHA Class >= II Heart Failure
• Child's B and C Cirrhosis
• Dialysis Requirement
• Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites
• Ages <18 years old
• Pregnant
• Incarcerated
• Unable to provide informed consent

Where it is running

• University of Southern California — Los Angeles, California, United States (enrolling)
• Ohio State University — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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