Creatine Supplementation in Pediatric Brain Injury

Starting soon · Not applicable · Has a placebo group

Conditions studied: Brain Injury, Traumatic Brain Injury, Stroke

In brief

A study examining the effects of creatine supplementation to improve recovery after brain injury in children and teenagers.

Key facts

Study ID

NCT07756060

Run by

Spaulding Rehabilitation Hospital

People needed

46

Starts

2026-10-01

Expected to finish

2030-09-01

Last updated by the study team

2026-08-10

Who can join

Age: 8 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of subacute moderate-to-severe brain injury resulting in a new functional impairment, as defined by: Glasgow Coma Scale score (GCS) < 13 points
• Subacute brain injury is defined to be < 3 months since index injury

You may not qualify if…

• Weight < 25 kg
• History pre-existing chronic kidney disease (CKD stage ≥ 2), prior kidney transplantation, previous dialysis dependence, or solitary kidney status
• Premorbid (pre-brain injury) eGFR < 60
• Inability to obtain regular phlebotomy for any reason
• Known inborn errors of mitochondrial function
• Premorbid history of significant head trauma or brain injury requiring hospitalization
• Pregnancy
• Concurrent malignancy
• Any other current, serious, chronic medical or psychiatric disease that in the PI's judgment may interfere with study participation or data integrity

Full record on ClinicalTrials.gov

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