Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
Running, not enrolling · Not applicable
Conditions studied: Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
In brief
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve knee osteoarthritis in adult men and women aged 18-75 with confirmed moderate knee osteoarthritis. The main questions it aims to answer are: * Does a single intra-articular injection of autologous ear-cartilage micrografts improve patients' clinical symptoms and knee function over 12 months? * What percentage of patients experience improvement in their complaints following treatment? * Do MRI scans show measurable improvement in knee cartilage condition 6 months after treatment? * Do inflammatory cytokine levels (IL-1β, IL-1α, IL-6, TNF-α) in joint fluid and cartilage tissue correlate with treatment response?
Key facts
- Study ID
- NCT07755579
- Run by
- Regenera Activa Worldwide S.L.
- People needed
- 33
- Starts
- 2023-05-22
- Expected to finish
- 2027-12-21
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed knee OA L-K grade II-III
- Symptomatic knee OA (with pain)
- Reduced mobility
You may not qualify if…
- Knee OA L-K grade IV
- Systemic Joint Disease (e.g. rheumatoid arthritis)
- Active autoimmune disease
- Active Oncologic process
- If other orthobiologic treatments administered in the last 3 months
Where it is running
- Semmelweis University — Budapest, Hungary
Full record on ClinicalTrials.gov
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