Effect of Oral Isotretinoin on Ocular Surface and Meibomian Glands

Completed · Not applicable

Conditions studied: Dry Eye Disease (DED), Meibomian Gland Dysfunction (Disorder), Acne Vulgaris

In brief

The aim of the study was to evaluate meibomian gland morphology using non-contact meibography and ocular surface changes in patients with acne vulgaris treated with isotretinoin as indicators of dry eye, which is known to be a side effect of isotretinoin.

Key facts

Study ID

NCT07753811

Run by

Benha University

People needed

60

Starts

2024-01-01

Expected to finish

2025-06-30

Last updated by the study team

2026-08-10

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with clinically diagnosed acne vulgaris with various degrees of severity candidates for oral isotretinoin treatment.
• Moderate to advanced stage of acne vulgaris.
• No significant improvement with local and systemic antibiotic therapy.
• Normal liver transaminase (AST, ALT) and lipid (Cholesterol, TG) levels

You may not qualify if…

• Patients with only comedonal acne.
• Prior use of systemic isotretinoin.
• Contact lens wearers.
• History of ocular trauma or surgery (within 1 year).
• Other systemic or dermatologic diseases.
• Active conjunctivitis or allergy.
• Use of medications affecting the ocular surface or meibomian glands. Lid deformity or abnormal lid movement

Where it is running

• faculty of Medicine — Banhā, Egypt

Full record on ClinicalTrials.gov

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