Flexible Nephroscopy-Assisted Single-Tract Versus Multi-Tract Percutaneous Nephrolithotomy for Complex Renal Stones

Starting soon · Not applicable

Conditions studied: Percutaneous Nephrolithotomy

In brief

This randomized, parallel-group, non-inferiority trial will compare flexible nephroscopy-assisted single-tract percutaneous nephrolithotomy with conventional multi-tract percutaneous nephrolithotomy in patients with complex unilateral renal stones. The primary outcome is stone-free rate at 3 months, and secondary outcomes include operative time, fluoroscopy time, hemoglobin drop, transfusion rate, hospital stay, complications, need for auxiliary procedures, and cost-effectiveness.

Key facts

Study ID

NCT07753733

Run by

Al-Azhar University

People needed

470

Starts

2026-07-30

Expected to finish

2028-08-30

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-70 years.
• Unilateral complex renal stones defined by one or more of the following: Guy's Stone Score III-IV, S.T.O.N.E. score ≥9, staghorn or partial staghorn calculus, or stones involving at least 3 calyces on NCCT.
• Preoperative expectation of multiple accesses by the surgeon.
• Written informed consent.

You may not qualify if…

• Solitary kidney.
• Uncorrected coagulopathy.
• Active urinary tract infection.
• ASA grade IV or higher.
• Pregnancy.
• Previous ipsilateral PCNL or open renal surgery.
• Stones less than 2 cm or simple calyceal stones.
• Refusal or inability to comply with follow-up.

Full record on ClinicalTrials.gov

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