Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System

Recruiting now

Conditions studied: Cardiac Diseases, Sickle Cell Disease, Hypertension, Diabetes Mellitus, Heart Failure, Congenital Heart Disease, Rheumatic Heart Disease, Epilepsy, Cancer, Mental Health Disorders, Kidney Disease

In brief

Cognizant of the prevalence of complicated non communicable diseases (NCD) and the attendant capacity problems faced by the health workers in primary care settings, we propose to adapt and pilot the Package of Essential Non-communicable Diseases (PEN) Plus intervention using the Interactive Systems Framework (ISF) and then implement and monitor the impact. The ISF framework proposes and organizes several implementation strategies to achieve Evidence Based Implementation (EBI) adaptation. We will apply these strategies at 2 first level hospitals (Peri-Urban and Rural) to ensure local adaptation and work towards scaling up of the WHO-PEN Plus in the rest of Zambia. This process will be inclusive, involving a Stakeholder Consultation Group that shall include the Zambian Non-Communicable diseases and injuries (NCDI) Poverty Commission and shall report bi-annually to a Project Advisory Board (PAB) chaired by the Permanent Secretary of the Ministry of Health.

Key facts

Study ID

NCT07753681

Run by

Centre for Infectious Disease Research in Zambia

People needed

2084

Starts

2022-08-08

Expected to finish

2027-09-30

Last updated by the study team

2026-08-07

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Presenting with chronic NCDs

You may not qualify if…

• Refusing to be followed up prospectively for routine visits

Where it is running

• Matero First Level Hospital — Lusaka, Lusaka Province, Zambia (enrolling)

Full record on ClinicalTrials.gov

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