Local Anesthetic Infiltration for Pain Control After Orthopedic Wide Excision

Starting soon · Not applicable · Has a placebo group

Conditions studied: Wide Excision, Postoperative Pain

In brief

This study evaluates whether injecting a local anesthetic mixture (ropivacaine, morphine, ketorolac, and epinephrine) under the skin at the incision site before wound closure reduces pain after orthopedic wide excision surgery for bone or soft tissue tumors. Participants will be randomly assigned to receive either the local anesthetic mixture or a saline control injection. Neither participants nor the study team assessing outcomes will know which treatment was given. The main goal is to determine whether this injection reduces the amount of opioid pain medication needed during the first 24 hours after surgery. The study will also assess pain scores, nausea and vomiting, and quality of recovery.

Key facts

Study ID

NCT07753629

Run by

Seoul National University Hospital

People needed

58

Starts

2026-08-07

Expected to finish

2028-07-31

Last updated by the study team

2026-08-07

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled to undergo elective orthopedic wide excision surgery under general anesthesia
• American Society of Anesthesiologists (ASA) Physical Status Classification 1, 2, or 3
• Age 19 years or older

You may not qualify if…

• Unwilling to provide informed consent
• History of allergy to local anesthetics
• History of chronic pain
• Use of opioid analgesics within 24 hours before surgery
• Active infection at the surgical site

Full record on ClinicalTrials.gov

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