Unipolar Radiofrequency Treatment Combined With SkinCeuticals A.G.E. Ultra Cream for Facial Rejuvenation

Recruiting now · Not applicable

Conditions studied: Facial Rejuvenation

In brief

To evaluate the efficacy and safety of monopolar radiofrequency treatment combined with SkinCeuticals A.G.E. Ultra Cream for facial rejuvenation

Key facts

Study ID

NCT07753564

Run by

Beijing Artemis Medical Beauty Clinic

People needed

50

Starts

2026-05-29

Expected to finish

2027-12-31

Last updated by the study team

2026-08-07

Who can join

Age: 30 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female, aged 30-60 years;
• Fine lines on both sides of the forehead meet Grade 1-5 according to the Skin Aging Atlas;
• Crow's feet on both sides meet Grade 2-5 according to the Skin Aging Atlas;
• Perioral wrinkles on both sides meet Grade 1-7 or nasolabial folds on both sides meet Grade 1-6 according to the Skin Aging Atlas;
• Lower facial laxity and sagging meet Grade 1-5 according to the Skin Aging Atlas;
• Subjects with consistent skin condition on both sides of the face who are scheduled to receive unipolar radiofrequency treatment;
• Able to comply well with the study requirements and maintain a regular lifestyle throughout the study period;
• Able to read and understand all contents of the informed consent form and voluntarily sign the ICF;
• Agree not to use any cosmetics, medications, or health supplements that may affect the study results during the trial period.

You may not qualify if…

• Allergic constitution or history of severe allergies (e.g., immediate hypersensitivity symptoms, allergic dermatitis);
• Presence of facial skin diseases (including severe freckles, atopic dermatitis, psoriasis, acute eczema, severe acne, etc.), skin infections (including viral, bacterial, fungal), or skin masses of unknown nature;
• Presence of large areas of birthmarks, scratch marks, vitiligo, pigmented nevi, keloids, or other skin manifestations on the face that may affect the evaluation;
• Presence of implantable electronic devices in the body (e.g., pacemaker, implantable cardioverter-defibrillator);
• Diagnosed with serious clinical conditions such as endocrine diseases, immune system diseases, severe organ failure, or malignant tumors;
• Diagnosed with severe mental illness or cognitive dysfunction, deemed by the investigator as unable to complete the evaluation or questionnaires involved in the study;
• Received or planned to receive facial radiofrequency or botulinum toxin treatment within 6 months prior to enrollment or during the study;
• Received chemotherapy or systemic corticosteroids within 3 months prior to enrollment;
• Received or planned to receive facial photoelectric treatments (e.g., laser, intense pulsed light), fillers (e.g., sodium hyaluronate, collagen), thread lifts, or other aesthetic procedures within 3 months prior to enrollment or during the study;
• Received or planned to receive facial mesotherapy or chemical peeling within 1 month prior to enrollment or during the study;
• Used cosmetics, skincare products, or topical medications with firming or anti-wrinkle claims (e.g., glycolic acid, salicylic acid, mandelic acid, tretinoin, hydroquinone, azelaic acid, adapalene, etc.) on the face within 14 days prior to enrollment;
• Other conditions that, in the investigator's judgment, render the subject unsuitable for unipolar radiofrequency treatment;
• Pregnant or breastfeeding women;
• Participated in other interventional clinical trials within 1 month prior to enrollment;
• Other circumstances under which the investigator considers the subject should not participate in this clinical trial.

Where it is running

• Beijing Artemis Medical Beauty Clinic — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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