A Prospective, Observational Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism

Starting soon

Conditions studied: Acute Kidney Injury

In brief

Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.

Key facts

Study ID

NCT07751874

Run by

University Hospital, Antwerp

People needed

50

Starts

2026-10-15

Expected to finish

2028-07-01

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Need for renal replacement therapy in the ICU with any of the following criteria:
• anticipation of severely impaired citrate metabolism (serum lactate ≥ 5 mmol/l in patients with shock or requirement of a dextrose drip to prevent hypoglycemia or spontaneous INR > 3 and/or requirement of fresh frozen plasma to maintain INR < 3 in patients with cirrhosis or acute liver failure or acute on chronic liver failure)
• development of citrate toxicity under CRRT with RCA due to worsening citrate metabolism

You may not qualify if…

• Pregnancy
• A known hypersensitivity to citrate compounds
• Refusal of informed consent

Where it is running

• Antwerp University Hospital — Edegem, Antwerp, Belgium

Full record on ClinicalTrials.gov

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