LLM-Driven Daily Conversation for Cognitive Health in Older Adults

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Conditions studied: Subjective Cognitive Decline

In brief

This study will develop and test a daily conversation platform that uses a large language model, a type of artificial intelligence, to support cognitive health in older adults at high risk of dementia. The platform will guide participants through voice-based conversations about topics that interest them. The conversations are designed to engage memory, attention, language, planning and problem-solving, and the ability to understand social situations. The platform will also analyze conversation data and create a report describing the participant's cognitive performance. The study has two stages. In the first stage, 15 participants will test the platform through two 20-minute conversation sessions. This group will include healthy younger adults, older adults with normal cognitive function, and older adults with cognitive difficulties. Participants will provide feedback on how easy and acceptable the platform is to use. In the second stage, 60 older adults at high risk of dementia will be randomly assigned to one of three groups. The groups will receive either conversation-based cognitive activities using the platform, interest-based news reading activities, or weekly health education while waiting to receive the intervention. The study activities will continue for 12 weeks. Researchers will compare changes in cognitive function, emotional well-being, loneliness, social connection, and user experience before and after the study. The main goals are to learn whether the platform is practical and acceptable for home use and whether it may help support cognitive and psychosocial health.

Key facts

Study ID

NCT07751510

Run by

Taipei Medical University Shuang Ho Hospital

People needed

75

Starts

2026-09-01

Expected to finish

2027-06-30

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Stage 1: Feasibility Study
• Participants must belong to one of the following groups:
• Healthy younger adults aged 18 to 40 years. Older adults with normal cognitive function aged 65 years or older and a Montreal Cognitive Assessment score of 24 or higher.
• Older adults with cognitive impairment aged 65 years or older and a Montreal Cognitive Assessment score of 18 to 23.
• Participants must have completed at least elementary school, corresponding to 6 or more years of education.
• Participants must be able to read and write Chinese, communicate in Chinese, and understand the study content.
• Participants must be able to use a tablet or smartphone independently or with assistance from a family member.
• Participants must have sufficient hearing and vision, with usual corrective devices if needed, to complete the study tasks.
• Stage 2: Preliminary Efficacy Study
• Participants must be aged 65 years or older.
• Participants must be considered at high risk of dementia by meeting at least one of the following conditions:
• Subjective cognitive decline:
• A Subjective Cognitive Decline Questionnaire score greater than 7 out of 24.
• A response of yes to both of the following questions:
• Compared with your previous usual condition, do you have memory problems? Have your family members or close contacts noticed memory problems compared with your previous condition? Performance within the normal range on standardized cognitive tests, defined as scores no more than 1.5 standard deviations below age- and education-adjusted norms on the Color Trails Test and memory-related assessments.
• Mild cognitive impairment:
• A diagnosis of mild cognitive impairment made by a neurologist or psychiatrist according to accepted diagnostic criteria.
• Evidence of memory performance at least 1.5 standard deviations below age- and education-adjusted normative values on at least one subtest of the Wechsler Memory Scale, Third Edition.
• Limited social interaction:
• Living alone, living with a person who cannot provide care, or living with a person who is absent for at least 3 days per week; or A score below 12 on the 6-item Lubben Social Network Scale.
• Chronic disease:
• A physician diagnosis of hypertension or diabetes for at least 1 year; and A need for ongoing medication or lifestyle management. Participants must have completed at least elementary school, corresponding to 6 or more years of education.
• Participants must be able to read and write Chinese, communicate in Chinese, and understand news and study-related content.
• Participants must be able to use a tablet or smartphone independently or with assistance from a family member.
• Participants must have sufficient hearing and vision, with usual corrective devices if needed, to complete the conversation and reading tasks.

You may not qualify if…

• A diagnosis of dementia or a severe neurodegenerative disorder, such as moderate-to-advanced Parkinson disease or Huntington disease.
• A history of a severe psychiatric disorder, such as schizophrenia or severe bipolar disorder, or current acute psychiatric symptoms that may interfere with understanding or responding during conversations.
• A major neurological event within the previous 6 months, such as stroke or severe traumatic brain injury, that may substantially affect cognitive or language function.
• Severe hearing, speech, or language impairment that prevents basic verbal communication, even when assistive devices are used.
• An acute medical illness, active infection, or any condition considered by a physician to make study participation inappropriate.
• Inability to complete a 20-minute conversation task or unwillingness to allow collection of interaction data.

Full record on ClinicalTrials.gov

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