15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis
Starting soon
Conditions studied: Osteoarthritis, Ankylosing Spondylitis
In brief
To evaluate serum and synovial fluid 15-PGDH levels in patients with osteoarthritis and ankylosing spondylitis and determine their associations with clinical and musculoskeletal ultrasound features. To compare 15-PGDH concentrations among patients with knee osteoarthritis, and ankylosing spondylitis with knee effusion To evaluate whether serum 15-PGDH reflects intra-articular 15-PGDH concentrations. Analysis the level of 15-PGDH in relation to disease activity and severity of both diseases.
Key facts
- Study ID
- NCT07751263
- Run by
- Assiut University
- People needed
- 51
- Starts
- 2026-08-02
- Expected to finish
- 2028-08-02
- Last updated by the study team
- 2026-08-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion criteria
- Adults aged 18 years or older. AxSpA group Patients diagnosed as ankylosing spondylitis according to ASAS criteria . R OA group
- Adults with osteoarthritis Diagnosed according to the American College of Rheumatology classification criteria.[8]R ACR Clinical classification criteria for Osteoarthritis of the hip ACR Clinical classification criteria for Osteoarthritis of the knee ACR Clinical classification criteria for Osteoarthritis of the hand Control group Age- and sex-matched healthy controls.
You may not qualify if…
- • Other inflammatory arthritides such as psoriatic arthritis, gout, or SLE-related arthritis.
- Septic arthritis or suspected joint infection.
- Recent intra-articular steroid injection if it may influence biomarker results.
- Any major systemic illness likely to affect biomarker measurement or ultrasound interpretation.
- Patients received certain drugs as non-steroidal anti-inflammatory drugs (NSAIDs)
Full record on ClinicalTrials.gov
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