Nerve Block and Perioperative Myocardial Injury in Elderly Hip Fracture
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Conditions studied: Hip Fracture, Perioperative Myocardial Injury, Myocardial Injury After Noncardiac Surgery
In brief
This single-center, retrospective cohort study evaluates whether a single preoperative peripheral nerve block can reduce the risk of perioperative myocardial injury in elderly patients undergoing delayed hip fracture surgery, defined as surgery performed more than 48 hours after injury. Hip fracture is a serious and common injury in older adults worldwide. When surgery cannot be performed within the recommended 48-hour window, patients face a much higher risk of heart muscle damage (myocardial injury), which is strongly linked to increased complications and death. Peripheral nerve blocks are a standard, safe method for pain control in hip fracture care, but their potential protective effect on the heart has not been specifically studied in patients with delayed surgery. This study will review medical records of patients aged 65 years and older who received hip fracture surgery at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 1, 2019 and December 31, 2025, with time from injury to surgery longer than 48 hours. Patients who received a single peripheral nerve block before surgery will be compared with patients who did not receive any peripheral nerve block. The main measure of the study is the rate of myocardial injury during hospital stay, detected by elevated troponin levels in routine blood tests. The study will also examine new-onset myocardial injury within 72 hours after surgery, major heart-related adverse events and all-cause death within 30 days after surgery, length of hospital stay, and other common postoperative complications. Researchers will also explore whether the timing of nerve block placement and different block techniques have different heart-protective effects. The findings may provide evidence for a simple, safe and practical strategy to reduce heart complications in older hip fracture patients who cannot receive timely surgery, and help clinicians improve perioperative care for this high-risk population.
Key facts
- Study ID
- NCT07751146
- Run by
- Tongji Hospital
- People needed
- 500
- Starts
- 2026-07-15
- Expected to finish
- 2027-07-05
- Last updated by the study team
- 2026-08-07
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 65 years
- Radiological evidence of non-pathological hip fractures (femoral neck, intertrochanteric or subtrochanteric fractures)
- Time from injury to surgery > 48 hours
- Underwent general anesthesia or intraspinal anesthesia
- Had at least one troponin I/T test result during preoperative or postoperative hospitalization
You may not qualify if…
- Preoperative presence of acute myocardial infarction (onset < 7 days), acute heart failure or sepsis
- Multiple fractures or concurrent surgeries at other sites
- Neuroblock as the sole anesthesia method
- Continuous nerve block or epidural analgesia
- Severe lack of key variables
Full record on ClinicalTrials.gov
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