Time Course of Respiratory Oscillometry Parameters During Nasal High-Flow Therapy in Stable Chronic Obstructive Pulmonary Disease
Starting soon · Not applicable
Conditions studied: Chronic Obstructive Pulmonary Disease (COPD)
In brief
Chronic obstructive pulmonary disease (COPD) can affect the small airways and alter respiratory mechanics. Nasal high-flow therapy delivers warmed and humidified gas through nasal cannulas and may change airway resistance. Respiratory oscillometry is a noninvasive test that measures respiratory resistance and reactance during quiet breathing. This prospective, single-center study will enroll 20 adults with severe or very severe stable COPD who have never used nasal high-flow therapy. During a single study visit lasting approximately 6 hours, participants will receive individualized nasal high-flow therapy for 4 hours. Respiratory oscillometry will be measured before exposure, immediately after device titration, and after 30, 60, 120, 180, and 240 minutes. The primary objective is to describe the time course of the difference between respiratory resistance measured at 5 hertz and at 20 hertz (R5-R20), an indirect index of peripheral airway mechanical abnormalities. Secondary objectives are to describe changes in total and proximal respiratory resistance, respiratory reactance, resonant frequency, and area of reactance. The hypothesis is that nasal high-flow exposure will produce measurable, time-dependent changes in respiratory oscillometry parameters.
Key facts
- Study ID
- NCT07750613
- Run by
- ADIR Association
- People needed
- 20
- Starts
- 2026-09-01
- Expected to finish
- 2028-02-29
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 years and <85 years;
- Chronic obstructive pulmonary disease classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometric grade III or IV;
- Modified Medical Research Council dyspnea score ≥2;
- Completed a pulmonary rehabilitation program at the study center;
- Clinically stable, defined as no exacerbation and no treatment change during the previous 4 weeks;
- With or without long-term oxygen therapy;
- Never previously used nasal high-flow therapy;
- Affiliated with a French social security system;
- Able to read and understand the participant information and provide written informed consent.
- Non-inclusion Criteria:
- Under legal guardianship or curatorship;
- Confirmed or suspected pregnancy;
- Unable to provide informed consent;
- Primary diagnosis of another chronic obstructive respiratory disease, such as asthma or primary bronchiectasis;
- Severe or unstable cardiovascular disease, including uncontrolled cardiac arrhythmia, severe heart failure, recent myocardial infarction, or unstable angina;
- Hemodynamic instability.
You may not qualify if…
- None
Where it is running
- ADIR Association — Rouen, Normandy, France
Full record on ClinicalTrials.gov
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