Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia Cases

Recruiting now · Not applicable

Conditions studied: Laryngomalacia

In brief

Laryngomalacia is the most common congenital laryngeal anomaly in children and is frequently associated with aspiration. This randomized controlled study aims to assess the role of proton pump inhibitor (PPI) therapy in reducing the incidence of aspiration in pediatric patients with laryngomalacia. Eligible participants will be randomly assigned to either a PPI treatment group or a control group. Clinical and swallowing assessments will be performed to compare aspiration incidence and swallowing outcomes between the two groups

Key facts

Study ID

NCT07750379

Run by

Minia University

People needed

60

Starts

2026-04-28

Expected to finish

2026-12-31

Last updated by the study team

2026-08-06

Who can join

Age: 1 and older, up to 5. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children diagnosed with laryngomalacia by laryngoscopic examination with a history of recurrent choking attacks or aspiration symptoms.
• Children aged from 6 months to 5 years.

You may not qualify if…

• Children with any neurological impairment.
• Children with other congenital anomalies.
• Children with other causes of respiratory distress

Where it is running

• faculty of Medicine, Minia University — Minya, Minya Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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