Nebulized Glubran 2-Assisted Tubeless PCNL Versus Conventional PCNL
Starting soon · Not applicable
Conditions studied: Kidney Calculi, Nephrolithiasis
In brief
This prospective randomized controlled study will compare two techniques used after percutaneous nephrolithotomy, a procedure for removing kidney stones. Participants with renal stones measuring 2-3 cm will be randomly assigned to either tubeless percutaneous nephrolithotomy with nebulized Glubran 2 used to seal the access tract or conventional percutaneous nephrolithotomy with placement of a nephrostomy tube. The study will evaluate whether the Glubran 2-assisted tubeless technique is safe and effective and whether it can reduce postoperative pain, bleeding, hospital stay, urine leakage, and other complications while maintaining a satisfactory stone-free rate.
Key facts
- Study ID
- NCT07749807
- Run by
- Benha University
- People needed
- 100
- Starts
- 2026-09-01
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older.
- Single or multiple renal stones measuring 2-3 cm.
- Renal stones located in an anatomical position suitable for percutaneous nephrolithotomy.
- Participant considered suitable for PCNL under general anesthesia.
- Ability and willingness to provide written informed consent.
You may not qualify if…
- Active urinary tract infection.
- Renal stones in an anomalous kidney.
- Uncontrolled hypertension.
- Uncontrolled diabetes mellitus.
- Uncorrected coagulopathy.
- Clinically significant arrhythmia.
- Distal ureteric obstruction.
- Fixed hip joints preventing appropriate operative positioning.
- Previous renal surgery.
- Requirement for more than one percutaneous puncture.
- Pelvicalyceal system perforation during the procedure.
- Excessive intraoperative bleeding.
- Any intraoperative finding requiring nephrostomy tube placement for safety.
Where it is running
- Benha University Hospital — Banhā, Qalyubia Governorate, Egypt
Full record on ClinicalTrials.gov
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