Hydrodissection-Assisted Bipolar Prostatic Enucleation Versus Conventional Bipolar Enucleation
Starting soon · Not applicable
Conditions studied: Prostatic Hyperplasia, Lower Urinary Tract Symptoms
In brief
This prospective randomized study will compare two surgical techniques for treating benign prostatic hyperplasia. Participants will be assigned to either hydrodissection-assisted bipolar prostatic enucleation-enucleoresection with transrectal ultrasound-guided subcapsular injection of diluted norepinephrine and methylene blue or conventional bipolar prostatic enucleation-enucleoresection without injection. The injected mixture is intended to separate the enlarged prostatic tissue from the surgical capsule and reduce bleeding during surgery. The study will evaluate whether the hydrodissection-assisted technique improves operative conditions, surgical outcomes, postoperative recovery, urinary symptoms, and urinary flow compared with the conventional technique.
Key facts
- Study ID
- NCT07749794
- Run by
- Benha University
- People needed
- 100
- Starts
- 2026-08-15
- Expected to finish
- 2027-08-15
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Benign prostatic hyperplasia.
- Prostate volume greater than 60 cc as measured by transrectal ultrasonography.
- Moderate-to-severe lower urinary tract symptoms, defined as an International Prostate - Symptom Score of 12 or higher.
- Failure of or poor response to medical management.
You may not qualify if…
- History of prostate cancer or suspicious findings on prostate biopsy.
- Active urinary tract infection.
- Severe cardiovascular, pulmonary, or other systemic comorbidities that contraindicate surgery.
- Previous prostate surgery, including transurethral resection of the prostate or open prostatectomy.
- Chronic urinary retention associated with neurogenic bladder. Hypersensitivity to norepinephrine or methylene blue.
Where it is running
- Benha University Hospital — Banhā, Qalyubia Governorate, Egypt
Full record on ClinicalTrials.gov
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