Pneumococcal Carriage Duration
Recruiting now
Conditions studied: Pneumococcal Carriage
In brief
Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.
Key facts
- Study ID
- NCT07748832
- Run by
- University of Central Florida
- People needed
- 60
- Starts
- 2026-07-21
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 0 and older, up to 4. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Are older than 28 days and under 4 years of age at the time of enrollment.
- Have a parent or legal guardian who:
- Provides written informed consent.
- Is able to read and speak English or Spanish.
- Agrees to comply with all study procedures, including completion of questionnaires and biweekly oropharyngeal (OP) swab collections from the child for a period of 12 months.
You may not qualify if…
- History of chronic medical conditions or immunocompromising conditions that may influence pneumococcal carriage or study participation, such as:
- cystic fibrosis
- cerebral palsy
- neuromuscular disorders
- congenital heart disease
- known congenital or acquired immunodeficiencies
- sickle cell disease
- undergoing immunosuppressive therapy (e.g., systemic corticosteroids ≥2 mg/kg/day for ≥14 days, chemotherapy, biologics)
Where it is running
- University of Central Florida — Orlando, Florida, United States (enrolling)
Full record on ClinicalTrials.gov
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