Micro-nanoplastic Exposure and Coronary Microcirculatory Dysfunction as Well as Cardiovascular Outcomes

Starting soon

Conditions studied: Coronary Microvascular Dysfunction (CMD), Microplastic Exposure, Nanoplastics, MACE

In brief

With strict quality control procedures applied throughout microplastic testing, this study will assess the association between baseline circulating micro-nanoplastic exposure and coronary microvascular dysfunction, as well as subsequent long-term cardiovascular outcomes.

Key facts

Study ID

NCT07748767

Run by

Beijing Anzhen Hospital

People needed

184

Starts

2027-01-01

Expected to finish

2029-12-31

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with clinical indications for invasive coronary angiography and coronary functional assessment;
• Voluntarily sign the written informed consent form.

You may not qualify if…

• History of previous myocardial infarction;
• History of prior PCI or coronary artery bypass grafting (CABG);
• Intraoperative coronary angiography shows non-left main coronary artery diameter stenosis >90%, or left main coronary artery diameter stenosis >50%;
• Left ventricular ejection fraction < 35%;
• Severe valvular heart disease with planned or prior valve replacement, confirmed cardiomyopathy, or constrictive pericarditis;
• Active inflammatory disease;
• Active malignant tumor or life expectancy < 1 year;
• Pregnant or lactating women;
• Subjects who refuse to comply with the pollution control measures set in this study;
• Currently participating in other interventional clinical trials.

Full record on ClinicalTrials.gov

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