Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery
Starting soon · Phase 4
Conditions studied: Obesity, Bariatric Surgery
In brief
This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to continuous desflurane anesthesia with respect to extubation time in adults undergoing elective laparoscopic bariatric surgery. Secondary outcomes include time to achieve a Patient State Index (PSi) greater than 80, time to achieve an Aldrete score of at least 8, incidence of postoperative nausea and vomiting, post-anesthesia care unit length of stay, and desflurane-related costs.
Key facts
- Study ID
- NCT07748247
- Run by
- Clínica Dávila
- People needed
- 82
- Starts
- 2026-08-03
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older.
- Scheduled for elective laparoscopic gastric bypass surgery.
- Body mass index between 30 and 50 kg/m².
- American Society of Anesthesiologists physical status II or III.
- Able and willing to provide written informed consent.
You may not qualify if…
- Surgical procedure lasting less than 2 hours.
- Body mass index greater than 50 kg/m².
- Significant cardiac disease.
- Moderate or severe obstructive respiratory disease, including uncontrolled asthma or chronic obstructive pulmonary disease.
- Pregnancy or breastfeeding.
- Known allergy or contraindication to medications used during the intraoperative period.
- Personal or family history of malignant hyperthermia.
- Active illicit drug use or substance dependence.
- Advanced chronic kidney disease, defined as an estimated glomerular filtration rate below 60 mL/min.
- Myasthenia gravis or another neuromuscular junction disorder.
- Severe cognitive or psychiatric disorder.
- Refusal to participate or withdrawal of informed consent at any time.
Where it is running
- Clínica Dávila — Santiago, Santiago Metropolitan, Chile
Full record on ClinicalTrials.gov
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