Retrospective Analysis of Early Gastric Cancer Patients Based on Prospective Clinical Dataset

Recruiting now

Conditions studied: Early Gastric Cancer

In brief

The goal of this retrospective observational cohort study is to describe the real-world clinicopathological characteristics, evolving treatment patterns, and long-term oncological outcomes of early gastric cancer (EGC) patients in China, utilizing a large prospective clinical database. The main questions it aims to answer are: How do different treatment modalities, including endoscopic resection, laparoscopic surgery, open surgery, and combined laparoscopic-endoscopic approaches, influence the long-term survival (Overall Survival and Disease-Free Survival) and recurrence patterns in Chinese EGC patients? What are the key clinicopathological factors affecting prognosis in this population? This study will retrospectively enroll approximately 5000 patients with histopathologically confirmed gastric adenocarcinoma staged as early gastric cancer (per AJCC 8th edition) from the information database of the National Clinical Research Center for Digestive Diseases. Researchers will systematically collect baseline demographics, treatment details, surgical complications, pathological staging, and longitudinal follow-up data (up to 10 years post-surgery) for all eligible patients. By comparing the short-term safety profiles and long-term survival benefits across different treatment groups and identifying risk factors for recurrence, this study aims to provide high-quality, China-specific evidence to guide standardized and individualized clinical decision-making for early gastric cancer.

Key facts

Study ID

NCT07747688

Run by

Beijing Friendship Hospital

People needed

5000

Starts

2026-05-08

Expected to finish

2027-06-08

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients aged between 18 and 90 years;
• preoperative endoscopic biopsy-confirmed gastric adenocarcinoma;
• clinical stage early gastric (cT1NxM0) cancer according to the AJCC 8th edition TNM staging system;
• patients who have signed a broad informed consent.
• Received primary treatment (including endoscopic resection, laparoscopic surgery, open surgery, or combined laparoscopic-endoscopic approach) at Beijing Friendship Hospital.

You may not qualify if…

• pregnant or breastfeeding women;
• Preoperative or intraoperative diagnosis remained indeterminate due to insufficient pathological or imaging evidence, such that the patient could not be clearly classified as early gastric cancer prior to treatment;
• Critical clinical data were severely incomplete or missing；
• Completely lost to follow-up with no available information to confirm survival status.

Where it is running

• Beijing Friendship Hospital, Capital Medical University — Beijing, China (enrolling)

Full record on ClinicalTrials.gov

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