Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients

Recruiting now

Conditions studied: Lung Transplantation, End Stage Lung Disease

In brief

The goal of this observational study is to evaluate respiratory and limb muscle properties in adults awaiting lung transplantation and determine how these measures relate to physical performance, symptoms, and recovery after transplantation. Respiratory and limb muscle weakness may contribute to impaired mobility, frailty, and delayed postoperative recovery, but their specific role in lung transplant candidates is not well understood. Participants will undergo muscle ultrasound imaging at weekly basis, respiratory and limb strength testing, physical performance assessments, and symptom questionnaires once before and after transplantation. Researchers will also collect information from medical records regarding intensive care unit stay, hospital length of stay, rehabilitation participation, and postoperative recovery outcomes.

Key facts

Study ID

NCT07747337

Run by

University of Florida

People needed

36

Starts

2026-02-05

Expected to finish

2027-07-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years or older.
• Hospitalized as potential candidates for single- or bilateral-lung transplant surgery.
• Hemodynamically stable for out-of-bed mobilization

You may not qualify if…

• Baseline cognitive impairment
• History of previous solid organ transplantation or thoracic surgery
• Existing phrenic nerve lesion
• Lower limb amputation or fracture
• External fixators or open wounds of the lower extremities
• Diagnosed neuromuscular disorder.
• Morbid obesity (body mass index >45 kg/m²).
• Any other medical condition that, in the opinion of the investigators, would make participation unsuitable.

Where it is running

• UF Health Shands Medical Center — Gainesville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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