Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial

Recruiting now · Phase 1/Phase 2

Conditions studied: Non Epileptic Seizures

In brief

Open label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)

Key facts

Study ID

NCT07747324

Run by

University of Sao Paulo

People needed

15

Starts

2026-07-01

Expected to finish

2027-08-30

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18 to 60 with documented PNES (confirmed via VEEG), without a diagnosis of comorbid epilepsy, and currently receiving follow-up care at outpatient clinics. To enroll in the study, patients must undergo a gradual reduction and discontinuation of any psychotropic medications (antidepressants, antipsychotics, benzodiazepines, or mood stabilizers/anticonvulsants) they are currently taking, in order to avoid drug interactions with-or influence on-the effects of ayahuasca.

You may not qualify if…

• Patients who have not experienced psychogenic seizures in the last 3 months; patients diagnosed with epilepsy; patients who refuse to reduce or discontinue their current psychotropic medications; patients with a history of prior ayahuasca use; patients with a history of substance use disorder; patients who refuse to sign the Informed Consent Form; patients with schizophrenia or other psychotic disorders and/or impaired reality testing; and pregnant or breastfeeding women.

Where it is running

• Ribeirão Preto Medical School — Ribeirão Preto, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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