Contact Lenses to Slow Myopia Progression in Adults

Starting soon · Not applicable

Conditions studied: Myopia, Myopia Progression

In brief

Myopia (nearsightedness) can continue to worsen during young adulthood, increasing the risk of sight-threatening eye diseases later in life. Although dual-focus soft contacts (DFSC) lenses have been shown to slow myopia progression in children, their effectiveness in adults is not well understood. This study will compare DFSC lenses with standard single-vision soft contact (SVSC) lenses in myopic young adults aged 18 to 30 years. Participants will be randomly assigned to wear one of the two lens types for 24 months. The study will measure changes in axial length and cycloplegic refractive error to determine whether DFSC lenses slow myopia progression in young adults.

Key facts

Study ID

NCT07747311

Run by

University of California, Berkeley

People needed

152

Starts

2026-09-01

Expected to finish

2030-09-30

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any gender, aged 18-30 years, inclusive.
• Successful previous contact lens wearer
• Documented ongoing myopia progression (at least 0.50D over past 2 years)
• Refractive error meeting the following by cycloplegic autorefraction:
• Myopia -0.50D to -5.00D SER in both eyes
• Astigmatism (absolute value) ≤ 1.50 D in both eyes
• Anisometropia < 1.50 D SER.
• Best-corrected distance visual acuity (BCDVA) in current correction as follows:
• 0.1 logMAR or better
• Interocular difference ≤ 0.1 log MAR

You may not qualify if…

• Current or previous use of pharmacologic or optical myopia control treatment within the past 2 years.
• Any ocular disease or abnormality affecting the cornea, lens, retina, iris, ciliary body, choroid, or sclera.
• History of manifest strabismus, amblyopia, or nystagmus.
• Previous eyelid, strabismus, intraocular, or refractive surgery. I- ntraocular pressure >26 mmHg.
• of premature birth (≥6 weeks before the due date).
• Neurological disorders, genetic syndromes, or other conditions that would interfere with completion of study procedures.
• Known allergy or hypersensitivity to fluorescein, proparacaine, or tropicamide.
• Conditions associated with degenerative myopia or abnormal ocular anatomy (e.g., Marfan syndrome, Stickler syndrome, retinopathy of prematurity, keratoconus, lenticonus, or spherophakia).
• Regular use of ocular medications, artificial tears, or wetting agents.
• Current use of systemic medications that may affect contact lens wear, tear film, pupil size, accommodation, electrophysiology, or refractive state.
• Diagnosis of or treatment for attention-deficit/hyperactivity disorder (ADHD) or a learning disability.
• Systemic disease that may affect visual function (e.g., diabetes mellitus).
• Ocular inflammation within 30 days before screening.
• Slit-lamp findings that contraindicate contact lens wear (e.g., corneal scars, corneal neovascularization, giant papillary conjunctivitis).
• Blepharospasm or other eyelid abnormalities that interfere with contact lens wear.
• Any severe ocular or systemic condition that, in the investigator's judgment, would interfere with study participation or follow-up.

Where it is running

• University Of California, Berkeley Myopia Research Group — Berkeley, California, United States

Full record on ClinicalTrials.gov

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