PROMISE Registry: PROspective Study on Management of Ischemic Stroke Secondary to mEvo Registry
Recruiting now
Conditions studied: Management of Ischemic Stroke, Medium Vessel Occlusion
In brief
Investigators are conducting a real world, observational, prospective, multicenter study to better understand treatment for patients with MeVo and distal vessel occlusions in the U.S post publication of recent MeVO trials.
Key facts
- Study ID
- NCT07746947
- Run by
- Indiana University
- People needed
- 652
- Starts
- 2026-07-11
- Expected to finish
- 2030-07-11
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Age >86
- ASPECTS ≤ 5
- Any intracranial hemorrhage on initial CT head non contrast
- mRS≥3
- Known pregnancy (local protocol to determine if patient is pregnant at the time of stroke)
- Known severe allergy (more than a rash) to contrast media uncontrolled by medications
- CT evidence of the following conditions:
- Midline shift or herniation
- Mass effect with effacement of the ventricles
- Acute bilateral strokes
- Contraindication to antiplatelet (aspirin, clopidogrel, ticagrelor, cangrelor) or contrast agents
- Intracranial tumors other than small meningioma that does not require surgery for one year post randomization.
- Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with an International Normalized Ratio (INR) of >3.0 or Partial Thromboplastin Time (PTT) >3 times of normal
- Baseline platelet count <80,000 per microliter (µl)
- Life expectancy is less than one year prior to stroke onset14. Participation in another randomized clinical trial that could confound the evaluation of the study outcomes
- Any other condition (in the opinion of the site investigator) that precludes an endovascular procedure or poses a significant hazard to the patient if an endovascular procedure was performed
Where it is running
- IU Health Neuroscience Center — Indianapolis, Indiana, United States (enrolling)
Full record on ClinicalTrials.gov
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