Reducing the Time Interval for Implant Placement After Extraction Socket Preservation Using BIOTECK Materials and OITECH Implant System

Starting soon

Conditions studied: Alveolar Bone Resorption

In brief

This randomized controlled clinical study aims to compare two healing periods (4 vs 6 months) after extraction socket preservation using equine-derived enzymatically treated biomaterials (BIOTECK® system), prior to implant placement with the OITECH implant system. The study evaluates whether early implant placement at 4 months provides comparable or non-inferior outcomes to the conventional 6-month protocol in terms of primary implant stability, bone quality, and histological bone regeneration. Secondary outcomes include marginal bone level maintenance, peri-implant tissue health, implant survival, and the incidence of complications during follow-up. The goal is to generate clinical evidence to optimize the timing of implant placement without altering established treatment protocols.

Key facts

Study ID

NCT07746869

Run by

Bioteck S.p.A.

People needed

40

Starts

2026-09-01

Expected to finish

2027-06-30

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: ≥ 18 years.
• Good general health. Need for extraction of incisors, canines, or premolars due to caries, endodontic complications, root fracture, or prosthetic reasons.
• Presence of three intact alveolar walls following tooth extraction, with a defect in the vestibular wall (<50%).
• Need for treatment with single-tooth implants, with adjacent teeth and occlusal antagonists present.
• Sufficient available bone, as assessed by CBCT, for the placement of implants 3.6 mm in diameter and 10 mm in length.
• Periodontal health with intact or reduced periodontium. Full-mouth plaque and bleeding scores < 20%.
• Ability and willingness to follow the study procedures and instructions.

You may not qualify if…

• Compromised health status. Presence of any systemic condition, such as uncontrolled diabetes mellitus, cancer, HIV, disorders that impair wound healing, chronic high-dose steroid therapy, intravenous and oral bisphosphonate therapy, metabolic bone diseases, a history of head and neck radiation, or any other immunosuppressive therapy that contraindicates oral surgical treatment.
• Absence of adjacent teeth or opposing occlusal teeth.
• The missing tooth is a molar.
• More than one defect in the bone wall or a buccal defect >50%.
• Allergy or hypersensitivity to medications or any product used during the study.
• Regular use of tobacco (defined as >1 cigarette per day) or chewing tobacco, even within the 3 months prior to enrollment.
• Untreated periodontitis.
• Acute periapical or periodontal infection.
• Oral plaque and/or bleeding > 20%.

Where it is running

• Unidad Clínica del Máster de Odontología Integral Avanzada e Implantología. Departamento de Estomatología. Universidad de Granada — Granada, Granada, Spain

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.