Gingival Graft vs T-PRF in Papilla Defects

Completed · Not applicable

Conditions studied: Papilla Reconstruction

In brief

Objective: Titanium-prepared platelet-rich fibrin (T-PRF) has emerged as a promising biomaterial in periodontal regenerative procedures. The aim of this study will be to compare the clinical effectiveness of de-epithelialized gingival grafts (DGG) and T-PRF in the reconstruction of deficient interdental papillae using the tunnel technique. Methods: A total of 34 patients presenting with 115 Class I and II interdental papilla defects will be enrolled in this study. Interdental papilla reconstruction will be performed using the tunnel technique in combination with either DGG or T-PRF. Demographic characteristics (age and sex), dentogingival variables (tooth shape, papilla location, jaw type, and papilla loss classification), and clinical parameters will be recorded. Clinical assessments will include probing depth (PD), gingival index (GI), plaque index (PI), gingival thickness (GT), keratinized tissue height (KTH), black triangle width (BTW), black triangle height (BTH), papilla fill percentage (%PF), and black triangle area (BTA). All clinical parameters will be assessed at baseline and at 1, 3, and 6 months following surgery.

Key facts

Study ID: NCT07746622
Run by: Pamukkale University
People needed: 34
Starts: 2022-11-15
Expected to finish: 2024-03-14
Last updated by the study team: 2026-08-05

Who can join

Age: 25 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age between 25 and 70 years.
Presence of papilla loss in the anterior region of the maxilla or mandible.
Classification of papilla loss as Class 1 or 2
Absence of systemic diseases.
No bleeding disorders that could interfere with the surgery.
Non-smoker and non-alcohol consumer.
Not pregnant or breastfeeding.
Absence of fillings, prostheses, or root canal treatments in the relevant teeth.
No prior surgical interventions in the target area.

You may not qualify if…

Smoking or alcohol consumption.
Presence of systemic diseases
Patients who did not attend postoperative follow-up appointments regularly.
Pregnant or breastfeeding individuals.

Where it is running

Pamukkale University Faculty of Dentistry — Denizli, Denizli, Turkey (Türkiye)
Faculty of Dentistry, Pamukkale University — Denizli, Pamukkale, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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