Network Modeling in Knee Osteoarthritis

Enrolling by invitation

Conditions studied: Chronic Musculoskeletal Pain

In brief

This project seeks to understand inter-individual differences in chronic musculoskeletal pain (cMSKP). Our long-term objective is to develop clinically-feasible decision tools that enable whole-person assessment and management of cMSKP and guide personalized primary, secondary and tertiary prevention strategies. Our secondary objective is to understand how inter-relationships between physiological, biomechanical and psychosocial factors change over time and impact the experience of living with chronic pain.

Key facts

Study ID

NCT07746284

Run by

George Mason University

People needed

200

Starts

2026-03-13

Expected to finish

2029-08-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18-years old or more
• Chronic pain for 3 months or more around the knee joint.

You may not qualify if…

• Acute pain due to knee injury or surgery within the past 3 months.
• Diagnosis of lumbar radiculopathy, neuropathy or neuritis.
• Special populations i. Adults unable to consent ii. Pregnant women (self-reported) iii. Prisoners iv. George Mason University Athletes
• Military
• Bleeding disorders, blood thinners, recent blood transfusions, vasovagal syncope, and current infection.

Where it is running

• Optimal Motion Physical Therapy — Herndon, Virginia, United States

Full record on ClinicalTrials.gov

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