Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis

Recruiting now · Early Phase 1

Conditions studied: Treatment of Stage III Periodontitis, Local Application of Insulin in Pockets

In brief

The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus hyaluronic acid as an adjunct to non surgical periodontal therapy in stage Ⅲ periodontitis patients. This will be done by: 1. Clinical assessment. 2. Biochemical analysis. - Dose the topical application of insulin or hyaluronic acid as an adjunct to non-surgical periodontal therapy improves periodontal condition in stage Ⅲ periodontitis patients? PICO P (Population): patients with stage Ⅲ periodontitis. I (Intervention): non surgical periodontal therapy (SRP) with topical application using insulin or hyaluronic acid in periodontal pockets. C (Comparison): topical application of insulin versus hyaluronic acid and SRP alone in periodontal pocket. O (Outcome): primary outcome: change in periodontal pocket depth (PPD) or clinical attachment loss (CAL). Secondary outcome: change in gingival index (GI) or bleeding on probing index (BOP) and levels of IL-1β in GCF of treated pocket. Study type: Randomized controlled trials (RCTs).

Key facts

Study ID

NCT07746206

Run by

Doaa Atta Aid

People needed

45

Starts

2026-07-24

Expected to finish

2026-07-25

Last updated by the study team

2026-08-04

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All selected patients are free from systemic illness as evaluated according to dental modification of the Cornell medical index.
• Should be diagnosed as having periodontitis.
• Not received any type of periodontal treatment in the past 6 months prior to examination.
• Should be cooperative, motivated, and willing to follow our treatment protocol and follow up visits.
• Not received antibiotics or anti-inflammatory therapy in the 6 months prior to examination.

You may not qualify if…

• Antibiotic therapy in the preceding 6 months or during study participation.
• History of insulin dependent diabetes and thyroid disease.
• Pregnancy, smoking, chronic diseases such as diabetes mellitus or rheumatoid arthritis, and allergy to ingredients in the drug.
• Poor oral hygiene compliance or inability to adhere to the clinical protocol.

Where it is running

• Alazhar university — Cairo, Egypt (enrolling)
• Faculty of Dental Medicine for Girls, Al-Azhar University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.