Managing Depressive Symptoms in ADPKD

Recruiting now · Not applicable

Conditions studied: Autosomal Dominant Polycystic Kidney Disease

In brief

The purpose of this research is to evaluate the feasibility and effectiveness of Digital Neurotherapy (DNT) or Capacity Coaching (CC) for managing symptoms of depression and self reported pain in Autosomal Dominant Polycystic Kidney Disease (ADPKD) compared to education alone.

Key facts

Study ID

NCT07745920

Run by

Mayo Clinic

People needed

105

Starts

2026-06-12

Expected to finish

2027-07-12

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed clinical diagnosis of ADPKD using Pei-Ravine criteria
• Pre-End Stage Kidney Disease, with Stage 1-5 CKD (eGFR >10 ml/min/1.73m2, with no anticipated dialysis or transplant within 12 months)
• Clinical or self-diagnosis of depression
• English-language fluency

You may not qualify if…

• Suicidal ideation/unstable mental illness of any kind
• Lack of access/ability to use internet-based programs
• eGFR <10 ml/min/1.73m2
• Anticipated dialysis or transplant within 6 months
• Prior chronic dialysis
• Prior organ (liver or kidney) transplant
• Lack of English language fluency
• Significant cognitive impairment (Mini Mental Status Exam (MMSE))

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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