Research On Advanced Diagnostics and Management of All Pregnancies to Prevent Stillbirth (ROADMAPS)

Starting soon

Conditions studied: Stillbirth

In brief

The primary objective of the Stillbirth Research Consortium (SBRC) longitudinal cohort study is to develop and evaluate a robust multivariable prediction model to identify pregnancies at \<14 weeks gestation that are at increased risk of stillbirth or fetal growth restriction (FGR), often reflecting underlying placental dysfunction. Secondary objectives include: * To evaluate placental pathology among cases and selected controls using standardized Amsterdam criteria. * To identify key aspects of perinatal nutrition contributing to placental dysfunction * To determine relationships between maternal biomarkers, placental pathology and energetics, with the goal of identifying biomarkers predictive of placental dysfunction * To develop a risk stratification model for pregnancies complicated by decreased fetal movements (DFM)

Key facts

Study ID

NCT07745101

Run by

RTI International

People needed

7000

Starts

2026-08-01

Expected to finish

2030-07-31

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• Evidence of fetal genetic anomaly or major structural malformation
• Known fetal aneuploidy based on chorionic villus sampling
• Positive cell-free fetal DNA screening for aneuploidy
• Multifetal gestation
• Less than 18 years of age
• Not fluent in either English or Spanish

Where it is running

• University of California Center for Stillbirth Prevention — San Diego, California, United States
• The Collaborative Action for Research to End Stillbirth (CARES) Research Center at Columbia University — New York, New York, United States
• Oregon Health & Science University — Portland, Oregon, United States
• University of Utah — Salt Lake City, Utah, United States
• Old Dominion University — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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