Glenohumeral OsteoArthritis Therapy Trial

Enrolling by invitation · Not applicable

Conditions studied: Glenohumeral Arthritis, Shoulder Arthritis Osteoarthritis

In brief

Arthritis of the shoulder glenohumeral joint is a growing problem in an aging population. Treatment options for glenohumeral arthritis can be grouped into three main categories: 1) shoulder replacement surgery, 2) injections (corticosteroid, hyaluronic acid and PRP) and physical therapy (PT). Surgery comes with risks and the potential for implant failure or revision over time. Therefore, it is typical for doctors to prescribe injections and/or PT before discussing surgery. Sometimes, insurance companies will require PT before considering a shoulder operation. It is unknown if PT is effective for improving function or pain with patients with glenohumeral arthritis. The aim of this study is to compare pain and functional outcomes after undergoing a 12 week PT program, at home PT exercises or delaying conservative treatment.

Key facts

Study ID

NCT07744542

Run by

State University of New York at Buffalo

People needed

125

Starts

2026-06-17

Expected to finish

2028-06-30

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient diagnosed with glenohumeral arthritis
• Patient > 18 years of age (adults)
• Patient provided written informed consent for study participation with IRB approved consent form
• Patient is willing and able to comply with scheduled clinical and radiographic evaluations and physical therapy regimen

You may not qualify if…

• -Have had corticosteroid injections in the affected shoulder(s) within 6 weeks of starting physical therapy.
• Those that have glenohumeral arthritis that is inflammatory, post traumatic or related to rotator cuff tear arthropathy in nature
• Have avascular necrosis of the glenohumeral joint
• Have failed a course of 6 weeks of physical therapy within the last year
• Have had surgery on the symptomatic shoulder in the past year
• Daily use of opioid (excluding tramadol or codeine).
• Have dementia
• Currently in a physical therapy program for more than 2 weeks
• Have planned total shoulder arthroplasty in the next 6 months.
• Live in a nursing home
• Additionally special populations listed below such as pregnant women, and prisoners will be excluded.

Where it is running

• UBMD Orthopaedics & Sports Medicine — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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