Hyaluronic Acid Crosslinking Clinical Study

Running, not enrolling · Not applicable

Conditions studied: Facial Aging, Skin Aging, Facial Volume Loss, Facial Rhytides, Nasolabial Fold, Lip Deformity, Jawline Contour Deformity, Chin Deformity

In brief

This prospective observational case series aims to evaluate the clinical efficacy, safety, and patient satisfaction associated with hyaluronic acid dermal fillers with different degrees of divinyl sulfone (DVS) crosslinking. Twenty adult participants undergoing facial aesthetic treatment will be followed for 90 days. Clinical outcomes will be assessed using three-dimensional imaging (Vectra® 3D), soft tissue ultrasonography, the Global Aesthetic Improvement Scale (GAIS), Net Promoter Score (NPS), Likert satisfaction scales, and standardized adverse event monitoring.

Key facts

Study ID

NCT07744464

Run by

Antony de Paula Barbosa

People needed

20

Starts

2026-03-01

Expected to finish

2026-12-30

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18 years or older. Male or female participants. Seeking facial aesthetic treatment with hyaluronic acid dermal fillers. Clinical indication for treatment according to the investigator's assessment. Willing and able to provide written informed consent. Willing to comply with all scheduled visits, assessments, and follow-up procedures.
• Able to undergo standardized photographic documentation, three-dimensional facial imaging (Vectra® 3D), ultrasonography, and patient-reported outcome assessments.

You may not qualify if…

• Pregnancy or breastfeeding. Known hypersensitivity to hyaluronic acid or any component of the dermal filler.
• Active infection, inflammation, or skin disease at the intended treatment site. Previous facial aesthetic procedure that could interfere with study assessments, according to the investigator's judgment.
• Participation in another clinical study that could affect study outcomes. Any medical condition considered by the investigator to make participation unsafe or interfere with study evaluations.
• Inability or unwillingness to complete the follow-up schedule or study assessments.

Where it is running

• Instituto Antony Barbosa — Belo Horizonte, Minas Gerais, Brazil

Full record on ClinicalTrials.gov

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