A Pilot Study Evaluating the Impact of a Prebiotic Soda on Gastrointestinal Symptoms in Users of GLP-1 Agonists

Completed · Not applicable

Conditions studied: GI Symptoms

In brief

The main objective of this study is to assess the impact of drinking a prebiotic soda on the gastrointestinal (GI) symptoms associated with the use of GLP-1 receptor agonists compared to usual fluid intake.

Key facts

Study ID

NCT07744360

Run by

Olipop, PBC

People needed

80

Starts

2026-02-10

Expected to finish

2026-06-04

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18 - 65 years old
• Currently on prescribed GLP-1 Agonist therapy (semaglutide and/or tirzepatide) for weight management for at least 1 week to 1 month AND experiencing at least one GI side effect (i.e., nausea, diarrhea, constipation, dyspepsia, abdominal pain)
• Not taking any prescription medications for side effect management
• Not taking fiber supplements to manage constipation
• Confirmation of planning to be on GLP-1 therapy for at least 3 more months
• Open to consuming a carbonated soda beverage
• In good general health at the time of screening
• Able to read and understand English
• Able to read, understand, and provide informed consent
• Able to use a personal smartphone device and download Chloe by People Science
• Able to receive shipment of the product at an address within the United States (No PO boxes, APO military PO boxes, Hawaii or Alaska addresses)
• Able to complete study assessments over the course of up to 13 weeks
• No known diagnosis of IBS or IBD

You may not qualify if…

• Do not have a personal smartphone, internet access, or unwilling to download Chloe
• Received any investigational therapies or treatments within 30 days prior to randomization.
• Have gastrointestinal illnesses
• Currently diagnosed with Alcohol Use Disorder and/or Substance Use Disorder
• Currently pregnant, planning to become pregnant in the next 4 months, or breastfeeding
• Any underlying medical conditions or comorbidities that may confound the assessment of digestive symptoms or the evaluation of the study outcomes
• Have a significant illness, disease or condition which, in the opinion of the principal investigator, may impact their ability to participate in the study or impact the study outcomes
• Known hypersensitivity or previous allergic reaction to OLIPOP prebiotic soda or any prebiotic beverage
• Are unlikely for any reason to be able to comply with the trial or considered unsuited for participation in the study by the Principal Investigator
• Current consumer of prebiotic sodas

Where it is running

• People Science — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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