Ciprofol Versus Propofol With Low-Dose Sufentanil for Painless Bronchoscopy

Completed · Phase 4

Conditions studied: Bronchoscopy, Procedural Sedation

In brief

Bronchoscopy may cause coughing, discomfort, body movement, and changes in breathing or blood pressure. Propofol is commonly used for sedation during bronchoscopy, but it may cause respiratory depression, circulatory depression, and injection pain. Ciprofol is another intravenous sedative that may provide effective sedation with fewer adverse effects. This study compared ciprofol combined with low-dose sufentanil with propofol combined with low-dose sufentanil in adults undergoing bronchoscopy under intravenous sedation. A total of 100 adults aged 35 to 65 years with no or mild systemic disease were randomly assigned in a 1:1 ratio to two treatment groups. Participants in one group received ciprofol and low-dose sufentanil, while participants in the other group received propofol and low-dose sufentanil. The study evaluated the amount of sedative used, adverse events, sedation onset time, recovery time, recovery quality, blood pressure, heart rate, oxygen saturation, and the overall effectiveness of anesthesia.

Key facts

Study ID

NCT07744061

Run by

Wenzhou Central Hospital

People needed

100

Starts

2022-08-01

Expected to finish

2022-12-31

Last updated by the study team

2026-08-04

Who can join

Age: 35 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 35 to 65 years.
• Body weight 45 to 80 kg.
• American Society of Anesthesiologists physical status I or II.
• Scheduled to undergo painless bronchoscopy.
• No contraindications to intravenous anesthesia.
• Willing and able to cooperate with study procedures.
• Provided written informed consent.

You may not qualify if…

• Body mass index greater than 40 kg/m².
• Uncontrolled hypertension, defined as systolic blood pressure greater than 180 mmHg.
• Severe cardiac arrhythmia.
• Unstable angina.
• Acute myocardial infarction within the previous 3 months.
• Acute exacerbation of asthma.
• Moderate to severe chronic obstructive pulmonary disease.
• Known allergy or hypersensitivity to any study anesthetic medication.
• Full-stomach status, intestinal obstruction, or gastric retention.
• Coagulation dysfunction or a clinically significant bleeding tendency.
• Mental illness or cognitive impairment that prevented cooperation with study procedures.

Where it is running

• Wenzhou Central Hospital — Wenzhou, Zhejiang, China

Full record on ClinicalTrials.gov

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