Gestational Response, Outcomes, and Weight After GLP-1 Use

Recruiting now

Conditions studied: Pregnant Individuals, Obesity & Overweight, Gestational Weight Gain

In brief

The goal of this observational study is to learn if using GLP-1RA medications for weight loss before pregnancy influences gestational weight gain and pregnancy outcomes. The main aims of the study are to: * Compare gestational weight gain between women with preconception GLP-1RA exposure and those without exposure. * Compare obstetrical outcomes between women with preconception GLP-1RA exposure and those without exposure. Researchers will compare pregnant women with a history of GLP-1RA use to pregnant women who have not used a GLP-1RA to compare differences. Participants will be asked to complete questionnaires at multiple timepoints during and after pregnancy that ask questions about medication history, thoughts and feelings around food, etc.

Key facts

Study ID

NCT07743567

Run by

University of Kansas Medical Center

People needed

400

Starts

2026-04-13

Expected to finish

2028-04-01

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Adult women
• Less than or equal to 20 weeks gestation at first visit
• English speaking

You may not qualify if…

• <18 years at time of initial visit
• Type 2 diabetes
• History of bariatric surgery
• Multiple gestation
• Cannot consent for themselves
• Cannot read and speak English
• Incarcerated

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

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