Effect of Preoperative Diclofenac Potassium Dose on Endodontic Pain

Starting soon · Not applicable · Has a placebo group

Conditions studied: Symptomatic Irreversible Pulpitis (SIP)

In brief

The aim of this study is to assess the effect of different doses of diclofenac potassium premedication (100mg vs 50mg) on anesthetic success of 4% articaine buccal infiltration and post-operative pain as compared to placebo in mandibular molars with symptomatic irreversible pulpitis.

Key facts

Study ID

NCT07743372

Run by

Cairo University

People needed

90

Starts

2026-08-01

Expected to finish

2028-02-01

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with symptomatic irreversible pulpitis.
• Patients with moderate to severe pain.
• Mandibular molars
• Patients with the ability to understand and use the pain scale

You may not qualify if…

• Patients allergic to any medication or material to be used in the study.
• Pregnant and lactating females.
• Patients taking medications affecting pain perception in the last 12 hours.
• Patients having more than one symptomatic molar in the same quadrant.
• Patients with contributory medical history (ASA I or II).

Full record on ClinicalTrials.gov

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