A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age
Starting soon · Phase 3
Conditions studied: Measles, Mumps, Rubella, Varicella (Chickenpox), Measles-Mumps-Rubella+Chickenpox Vaccine
In brief
The purpose of this study is to evaluate how consistently 3 different manufacturing lots of the GSK's investigational measles, mumps, rubella, and varicella (MMRVNS) vaccine will produce an immune response. It will also compare the overall immune response to the MMRVNS vaccine with that of the Merck licensed measles, mumps, rubella, and varicella (MMRV) vaccine. The vaccines will be given as a second dose to children aged 4 to 6 years who have previously received a first dose of any combination of measles, mumps, rubella, and varicella-containing vaccine(s). The study will also assess the immune response and safety of the MMRVNS and MMRV vaccines when given at the same time as a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus (DTaP-IPV) vaccine. The DTaP-IPV vaccine used is licensed as Kinrix in the United States.
Key facts
- Study ID
- NCT07742644
- Run by
- GlaxoSmithKline
- People needed
- 1860
- Starts
- 2026-08-11
- Expected to finish
- 2028-11-21
- Last updated by the study team
- 2026-08-03
Who can join
Age: 4 and older, up to 6. Sex: any. Healthy volunteers: accepted.
Where it is running
- Applied Research Center of Arkansas — Little Rock, Arkansas, United States
- Century Research Institute Inc — Huntington Park, California, United States
- Matrix Clinical Research — Los Angeles, California, United States
- Center for Clinical Trials of Sacramento, Inc. — Sacramento, California, United States
- Center for Clinical Trials of San Gabriel — West Covina, California, United States
- BioMD Clinical Research — Coral Gables, Florida, United States
- D&H Pompano Research Center LLC — Margate, Florida, United States
- PAS Research — Tampa, Florida, United States
- Medical Research Partners — Ammon, Idaho, United States
- Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
- Kentucky Pediatric/ Adult Research — Bardstown, Kentucky, United States
- Norton Childrens Research Institute — Louisville, Kentucky, United States
- Benchmark Research — Covington, Louisiana, United States
- ACC Pediatric Research — Haughton, Louisiana, United States
- Velocity Clinical Research, Gulfport — Lafayette, Louisiana, United States
- Jefferson City Medical Group PC — Jefferson City, Missouri, United States
- Boeson Research MSO — Missoula, Montana, United States
- Midwest Children's Health Research Institute, LLC — Lincoln, Nebraska, United States
- Midwest Children's Health Research Institute, LLC — Lincoln, Nebraska, United States
- Complete Children's Health — Lincoln, Nebraska, United States
- Complete Children's Health — Lincoln, Nebraska, United States
- Atrium Health — Charlotte, North Carolina, United States
- Senders Pediatrics — Cleveland, Ohio, United States
- Neighbors Clinical Research — Charleston, South Carolina, United States
- Children's Clinic of Jonesboro, AR — Jonesboro, Arkansas, United States
Full record on ClinicalTrials.gov
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