Oxytocin in Postmenopausal Women

Starting soon

Conditions studied: Postmenopausal, Premenopausal

In brief

The aim of the present study is to assess whether cumulative endogenous neurophysin I secretion over one month differs between premenopausal and postmenopausal women. Using repeated measurements of neurophysin-I (NP-I, equimolar surrogate marker of oxytocin) across defined physiological time points, this study investigates oxytocin system regulation under cyclic and non-cyclic hormonal conditions. The primary hypothesis is that cumulative NP-I release, expressed as the area under the curve (AUC) is lower in the postmenopausal group compared to the premenopausal group.

Key facts

Study ID

NCT07742124

Run by

University Hospital, Basel, Switzerland

People needed

30

Starts

2027-06-01

Expected to finish

2027-09-01

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female sex at birth
• Age ≥18 years
• Premenopausal group:
• Premenopausal women aged 18-35 years with regular menstrual cycles (21-35 days) for ≥3 months prior to study entry
• Postmenopausal group:
• Postmenopausal women ≥2 years of postmenopause (i.e. 3 years since last menstrual period (LMP), with menopause defined as ≥ 12 months of amenorrhea)

You may not qualify if…

• Pregnancy or breastfeeding
• Use of hormonal contraception or hormone replacement therapy within the last 3 months
• Known endocrine disorders affecting the hypothalamic-pituitary-gonadal axis
• Use of medications
• Severe depression (BDI score > 28 points), any other severe psychiatric illness or acute medical disease
• Inability to comply with study procedures
• Participation in a trial with investigational drugs within the last 30 days

Where it is running

• University Hospital Basel — Basel, Canton of Basel-City, Switzerland

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.