Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity
Starting soon · Not applicable · Has a placebo group
Conditions studied: Mild Cognitive Impairment (MCI)
In brief
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are: * Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways? Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics) Participants will: * Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.
Key facts
- Study ID
- NCT07741773
- Run by
- Augusta University
- People needed
- 20
- Starts
- 2026-09-01
- Expected to finish
- 2028-08-31
- Last updated by the study team
- 2026-08-03
Who can join
Age: 50 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.
You may not qualify if…
- History or presence of vascular disease that may affect cognitive function
- History or presence of stroke within the past 1 year
- Recent transient ischemic attack (TIA) within the past 180 days
- History of severe, clinically significant CNS trauma
- History of intracranial tumor
- History or presence of kidney disease (eGFR <60 mL/min/1.73m2)
- Presence of a pacemaker
- Presence of metal in the body
- Allergic to the MRI contrast agent "Multihance"
- Pregnancy
Where it is running
- Georgia prevention institute — Augusta, Georgia, United States
Full record on ClinicalTrials.gov
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