Sequential Order of RSI on Tracheal Intubation

Completed · Not applicable

Conditions studied: Tracheal Intubation, Rapid Sequence Induction and Intubation

In brief

This clinical trial aims to understand the effect of the order of administration of Neuromuscular Blocking Agents (NMBAs) and sedatives on the success rate of intubation during Rapid Sequence Intubation (RSI) in the emergency department. The main questions to be answered include: 1. The impact of sequential drug administration order during rapid sequence induction (RSI) on first-pass intubation success rates. 2. Time to successful intubation 3. Hypoxia incidence (SpO₂ \<90%) 4. Risk of post-traumatic stress disorder (PTSD) 5. Procedure-related complications

Key facts

Study ID

NCT07741578

Run by

Zhongnan Hospital

People needed

380

Starts

2025-07-01

Expected to finish

2026-06-30

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• in ED/EICU required emergency intubation
• RSI required

You may not qualify if…

• Pregnancy
• do not intubation orders
• Declined participation
• Other trials
• Non-emergent cases
• Active CPR

Where it is running

• Zhongnan Hospital of Wuhan University — Wuhan, China

Full record on ClinicalTrials.gov

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