Povidone Iodine for Caries Prevention

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Dental Caries

In brief

The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to answer are: 1. How will home use of Povidone Iodine, as an adjunct treatment to standard dental care, reduce the incidence of tooth decay? 2. How will home use of Povidone Iodine reduce the mouth germs responsible for tooth decay? 3. If Povidone Iodine use is accompanied by probiotic use, will its effectiveness be even better than Povidone Iodine alone? Participants will: 1. Provide a plaque sample at the beginning of the study. 2. Swab their children's teeth once a week for one month and then monthly thereafter. Some participants may be asked to use probiotic drops nightly after brushing their teeth. 3. Keep a record of compliance. 4. Return every 6 months for a dental exam and to provide a plaque sample. Keep a diary of their symptoms and the number of times they use a rescue inhaler

Key facts

Study ID

NCT07741409

Run by

Jeffrey A. Banas

People needed

174

Starts

2026-08-03

Expected to finish

2028-06-30

Last updated by the study team

2026-08-03

Who can join

Age: 1 and older, up to 3. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 1 to 3 years of age
• No plans to relocate in the next 12 months

You may not qualify if…

• Thyroid condition
• Antibiotic usage in the prior 3 months

Where it is running

• University of Iowa College of Dentistry — Iowa City, Iowa, United States

Full record on ClinicalTrials.gov

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