Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer

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Conditions studied: Chatbot, Large Language Model, Adolescent and Young Adult Cancer Survivors, Reproductive Health

In brief

Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years. Large language models (LLMs) offer a promising solution to bridge onco-fertility service gaps by integrating evidence-based knowledge and therapeutic frameworks. This pilot randomized controlled trial aims to assess the feasibility and preliminary effectiveness of an LLM-driven chatbot versus electronic brochure in addressing reproductive concerns among AYA cancer survivors.

Key facts

Study ID

NCT07741266

Run by

The Hong Kong Polytechnic University

People needed

60

Starts

2026-09-01

Expected to finish

2027-06-30

Last updated by the study team

2026-08-03

Who can join

Age: 15 and older, up to 39. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• (1) 15-39-year-old females; (2) cancer diagnosis between ages 15-39; (3) current or prior concerns regarding fertility; (4) proficiency in Mandarin Chinese; and (5) access to a mobile device for intervention delivery.

You may not qualify if…

• (1) Involvement in the chatbot co-design phases; (2) inability to provide informed consent; (3) significant sensory, cognitive, or psychological impairments precluding meaningful participation; and (4) acute illness at the time of recruitment.

Where it is running

• The University of Science and Technology of China — Hefei, Anhui, China
• The Hong Kong Polytechnic University — Kowloon, Hong Kong

Full record on ClinicalTrials.gov

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