Biomarker Analysis Data From a Randomized Phase II Study in Patients With Nasopharyngeal Carcinoma Treated With Chemotherapy and Radiotherapy

Completed

Conditions studied: Nasopharyngeal Carcinoma (NPC)

In brief

Clinicopathological and genomic data (Next generation sequencing and IHC/CISH) in available tissues were performed in patients with nasopharyngeal carcinoma who participated in a previously conducted randomized phase II study that evaulated induction chemotherapy followed by CCRT with CCRT alone.

Key facts

Study ID

NCT07741110

Run by

Hellenic Cooperative Oncology Group

People needed

141

Starts

2003-10-01

Expected to finish

2008-02-28

Last updated by the study team

2026-08-03

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• biopsy-proven, previously untreated WHO type I, II or III NPC;
• age > or equal to 15 years
• stage IIB-IVB according to the American Joint Committee on Staging of Cancer classification (AJCC 2002);
• measurable or evaluable disease
• no other primary tumors
• performance status (PS) of 0-2 according to the Eastern Cooperative Oncology Group scale (ECOG)
• adequate bone marrow, hepatic, renal and pulmonary function
• adequate nutritional status to tolerate protocol treatment and
• adequate mental status to follow instructions, keep appointments and provide written informed consent.

You may not qualify if…

• Secondary malignancies
• age< 15 years
• ECOG PS 3-4
• Renal, hepatic, hematologic or pulmonary insufficiency

Full record on ClinicalTrials.gov

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