Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery

Starting soon · Phase 4

Conditions studied: Emergence Agitation, General Anesthesia, Nasal Surgical Procedures

In brief

Emergence agitation (EA) is a common complication during recovery from sevoflurane anesthesia, particularly after nasal surgery. Although remimazolam 0.1 mg/kg has been shown to reduce the incidence of EA, this dose may produce excessive sedation and increase the risk of intraoperative burst suppression. This randomized, double-blind, non-inferiority trial will compare low-dose remimazolam (0.03 mg/kg) with the standard dose (0.1 mg/kg) administered at the end of surgery in adult patients undergoing nasal surgery under sevoflurane anesthesia. The primary objective is to determine whether low-dose remimazolam is non-inferior to the standard dose in preventing emergence agitation. Secondary outcomes include burst suppression, recovery profiles, and safety outcomes.

Key facts

Study ID

NCT07740655

Run by

Jeju National University School of Medicine

People needed

138

Starts

2026-07-24

Expected to finish

2027-07-31

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 79 years.
• Scheduled to undergo elective nasal surgery under sevoflurane-based general anesthesia at Jeju National University Hospital.
• Able to provide written informed consent.

You may not qualify if…

• Contraindications to remimazolam.
• History of allergy or hypersensitivity to benzodiazepines.
• Inability to provide informed consent due to cognitive impairment.
• Preexisting psychiatric disorders.
• History of alcohol or substance abuse.
• Inability to assess the Riker Sedation-Agitation Scale (SAS).
• Body mass index (BMI) > 40 kg/m².

Where it is running

• Jeju National University Hospital — Jeju City, Jeju-do, South Korea

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.