Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Spinal Cord Injuries (SCI)

In brief

This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.

Key facts

Study ID

NCT07739992

Run by

Milap Sandhu

People needed

40

Starts

2026-07-27

Expected to finish

2028-07-01

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Chronic Spinal Cord Injury (>6 months)
• Motor incomplete SCI classified as AIS C or D
• Volitional ankle plantarflexion strength in at least one leg

You may not qualify if…

• Uncontrolled hypertension (outside 140/90 and 90/60)
• Concurrent medical illness
• Traumatic brain injury
• Cardiovascular complications
• Pulmonary complications
• Metabolic dysfunction
• Continued use of anti-spasticity medications
• Previously diagnosed obstructive sleep apnea

Where it is running

• Shirley Ryan AbilityLab — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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